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《医学前沿(英文)》 2017年 第11卷 第4期 页码 509-521 doi: 10.1007/s11684-017-0546-3
Hepatocellular carcinoma (HCC) is currently the fifth most common malignancy and the third leading cause of cancer-related mortalities worldwide. In the last few years, treatments for HCC have significantly improved from a mere surgical resection to a series of minimally invasive therapies and targeted drugs. However, recurrence frequently occurs even upon curative therapeutics, and drug therapies generally produce disappointing results, with the overall prognosis dismal. This challenging clinical scenario warrants new effective and life-prolonging strategies for patients with HCC. Compelling evidence suggests that NK cells play a critical role in the immune function of the liver and in the immune defenses against HCC, indicating that HCC might be an ideal target for NK cell-based immunotherapies. To obtain comprehensive insights into the putative influence of NK cells on HCC, this paper summarizes current knowledge on NK cells in HCC and discusses the usefulness and prospects of NK cell-based immunotherapies. Critical issues that require consideration for the successful clinical translation of NK cell-based therapies are also addressed. If appropriately used and further optimized, NK cell-based therapies could dominate important roles in the future immunotherapeutic market of HCC.
关键词: natural killer cell hepatocellular carcinoma immunotherapy
《环境科学与工程前沿(英文)》 2023年 第17卷 第3期 doi: 10.1007/s11783-023-1631-2
● All 1,4-naphthoquinone hybrids exhibited significant antimicrobial activity.
关键词: 1 4-naphthoquinone derivatives Antibacterial Action mechanism RecA
TAN Guang, WANG Zhongyu, CHE Luanqing, YIN Shuo
《医学前沿(英文)》 2007年 第1卷 第1期 页码 41-45 doi: 10.1007/s11684-007-0008-4
《化学科学与工程前沿(英文)》 2022年 第16卷 第1期 页码 112-120 doi: 10.1007/s11705-021-2075-5
关键词: fluorescent drug lysosomal anticancer zebrafish nude-mouse tumour imaging
Jianhong XI,Mengchang HE,Kunpeng WANG,Guizhi ZHANG
《环境科学与工程前沿(英文)》 2015年 第9卷 第6期 页码 970-978 doi: 10.1007/s11783-014-0716-3
关键词: Sb(III) Sb(V) determination masking agents hydride generation (HG-AFS)
Mehvish Mumtaz, Yixiang Bao, Wenchao Li, Lingxiao Kong, Jun Huang, Gang Yu
《环境科学与工程前沿(英文)》 2019年 第13卷 第5期 doi: 10.1007/s11783-019-1145-0
关键词: Textile finishing agents Kendrick mass defect Total oxidizable precursor assay
Discovery of novel ursolic acid derivatives as effective antimicrobial agents through a ROS-mediated
《化学科学与工程前沿(英文)》 2023年 第17卷 第12期 页码 2101-2113 doi: 10.1007/s11705-023-2361-5
关键词: ursolic acid antibacterial activities reactive oxygen species apoptosis
Discovery of cryptolepine derivatives as novel promising agents against phytopathogenic bacteria
《化学科学与工程前沿(英文)》 2023年 第17卷 第2期 页码 156-166 doi: 10.1007/s11705-022-2196-5
关键词: cryptolepine derivatives phytopathogenic bacteria antibacterial activity mechanism of action
BIOINSECTICIDES AS FUTURE MAINSTREAM PEST CONTROL AGENTS: OPPORTUNITIES AND CHALLENGES
《农业科学与工程前沿(英文)》 2022年 第9卷 第1期 页码 82-97 doi: 10.15302/J-FASE-2021404
Bioinsecticides are naturally-occurring substances from different sources that control insect pests. Ideal bioinsecticides should have low toxicity to non-target organisms. They should also be easily degraded in sewage treatment works and natural environments, highly effective in small quantities and affect target pests only. Public concerns about possible side-effects of synthetic pesticides have accelerated bioinsecticide research and development. However, to develop bioinsecticides into mainstream products, their high production costs, short shelf-life and often uncertain modes of action need to be considered. This review summarizes current progress on bioinsecticides which are categorized as biochemical insecticides and their derivatives, plant-incorporated protectants, and microbial bioinsecticides. The current constraints that prevent bioinsecticides from being widely used are discussed and future research directions are proposed.
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《医学前沿(英文)》 2016年 第10卷 第4期 页码 517-521 doi: 10.1007/s11684-016-0480-9
This study aimed to compare the antimicrobial activities of topical agents against Propionibacterium acnes isolated from patients admitted to a hospital in Shanghai, China. The minimal inhibitory concentrations of the cultured P. acnes were determined in accordance with the Clinical and Laboratory Standards Institute. Susceptibilities to clindamycin and erythromycin were compared in terms of gender, age, disease duration, previous treatment, and disease severity. A total of 69 P. acnes strains were isolated from 98 patients (70.41%). The susceptibility to triple antibiotic ointment (neomycin/bacitracin/polymyxin B) and bacitracin was 100%. The susceptibility to fusidic acid was 92.7%. The resistance rates to neomycin sulfate, erythromycin, and clindamycin were 11.7%, 49.3%, and 33.4%, respectively. The high resistance rate to clindamycin and erythromycin was significantly affected by gender, previous treatment, and disease severity rather than by age and disease duration. Topical antibiotics should not be used separately for long-term therapy to avoid multiresistance. The use of topical antibiotics should be determined by clinicians on the basis of clinical conditions.
关键词: antimicrobial susceptibility/resistance Propionibacterium acnes topical antibiotics in vitro study
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《医学前沿(英文)》 2015年 第9卷 第1期 页码 46-56 doi: 10.1007/s11684-015-0375-1
Sickle cell disease (SCD) is an inherited disorder of hemoglobin in which the abnormal hemoglobin S polymerizes when deoxygenated. This polymerization of hemoglobin S not only results in hemolysis and vaso-occlusion but also precipitates inflammation, oxidative stress and chronic organ dysfunction. Oxidative stress is increasingly recognized as an important intermediate in these pathophysiological processes and is therefore an important target for therapeutic intervention. The transcription factor nuclear erythroid derived- 2 related factor 2 (Nrf2) controls the expression of anti-oxidant enzymes and is emerging as a protein whose function can be exploited with therapeutic intent. This review article is focused on triterpenoids that activate Nrf2, and their potential for reducing oxidative stress in SCD as an approach to prevent organ dysfunction associated with this disease. A brief overview of oxidative stress in the clinical context of SCD is accompanied by a discussion of several pathophysiological mechanisms contributing to oxidative stress. Finally, these mechanisms are then related to current management strategies in SCD that are either utilized currently or under evaluation. The article concludes with a perspective on the potential of the various therapeutic interventions to reduce oxidative stress and morbidity associated with SCD.
关键词: oxidative stress Nrf2 triterpenoids sickle cell disease vaso-occlusion CDDO-Me
Self-etching adhesives: possible new pulp capping agents to vital pulp therapy
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《医学前沿(英文)》 2011年 第5卷 第1期 页码 77-79 doi: 10.1007/s11684-010-0104-8
Pulp capping is one of the solving for keeping vital pulp in the case of dentin caries, reversible pulpitis or traumatic pulp exposure. The presence of bacteria on the cavity walls or in the pulp was the major factor that leads to the failure of pulp capping. Traditional pulp capping agent, calcium hydroxide, may not prevent microleakage. Self-etching system is a newly developed adhesive system, which could provide less microleakage and would not break down or dissolve, preventing the oral fluids and bacteria from the pulp along the cavity wall. This may reduce such clinical problems as postoperative sensitivity, secondary caries and marginal discoloration. Researches showed that some kinds of self-etching adhesives induced the mild to moderate inflammatory pulp response, with negative bacterial staining. Inclusion of antibacterial components into self-etching system, such as 12- methacryloyloxydodecylpyridinium bromide (MDPB) may inhibit bacteria and provide better clinical effects. It is speculated that using the self-etching adhesive system containing the antibacterial agent, such as MDPB, to the dental pulp directly or indirectly, may inhibit bacteria after the placement of restoration as well as residual bacteria in the cavity.
关键词: dental pulp pulp capping self-etching adhesives antibacterial components
Etiology of invasive candidosis agents in Russia: a multicenter epidemiological survey
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《医学前沿(英文)》 2018年 第12卷 第1期 页码 84-91 doi: 10.1007/s11684-017-0612-x
A multicenter prospective epidemiological survey on the etiologic agents of invasive candidosis was conducted in Russia in the period of 2012–2014. Samples were collected from 284 patients with invasive candidosis and Candida species isolated by culture. The species were identified by DNA sequencing and MALDI-TOF mass-spectrometry. A total of 322 isolates were recovered, in which 96% of Сandida species belonged to six major species, namely, C. albicans (43.2%), C. parapsilosis (20.2%), C. glabrata (11.5%), C. tropicalis (9.6%), C. krusei (6.2%), and C. guilliermondii (5.3%). Most Candida species were isolated from blood samples (83.23%). Notably, the prevalence rate of C. albicans reduced from 52.38% to 32.79% (2012 vs. 2014) (P=0.01) whereas that of non-C. albicans increased from 47.62% (2012) to 67.21% (2014) (P<0.01). Species distribution differed among geographical regions; specifically, the prevalence rate of C. albicans as an etiologic agent of invasive candidosis in Siberian Federal region was significantly higher than that in other Federal regions. Results indicated a shift from C. albicans to non-C. albicans. Therefore, a detailed investigation on the contributing factors and appropriate treatment of invasive candidosis is needed.
关键词: prevalence &Scy andida species invasive candidosis nosocomial etiology MALDI-TOF mass-spectrometry candidemia
针对意外崩溃智能体的教练辅助多智能体强化学习框架 Research Article
赵鉴1,赵有朋1,王维埙2,阳明宇1,胡迅晗1,周文罡1,郝建业2,李厚强1
《信息与电子工程前沿(英文)》 2022年 第23卷 第7期 页码 1032-1042 doi: 10.1631/FITEE.2100594
关键词: 多智能体系统;强化学习;意外崩溃智能体
J. A. RINCON,J. BAJO,A. FERNANDEZ,V. JULIAN,C. CARRASCOSA
《信息与电子工程前沿(英文)》 2016年 第17卷 第4期 页码 325-337 doi: 10.1631/FITEE.1500343
关键词: Multi-agent systems Virtual environments Emotional agents
标题 作者 时间 类型 操作
Natural killer cells in hepatocellular carcinoma: current status and perspectives for future immunotherapeutic
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期刊论文
Evaluation of 1,4-naphthoquinone derivatives as antibacterial agents: activity and mechanistic studies
期刊论文
Immunotherapeutic effects on murine pancreatic carcinoma by β-elemene combined with dendritic cells modified
TAN Guang, WANG Zhongyu, CHE Luanqing, YIN Shuo
期刊论文
Novel lysosome-targeted anticancer fluorescent agents used in zebrafish and nude mouse tumour imaging
期刊论文
Comparison of masking agents for antimony speciation analysis using hydride generation atomic fluorescence
Jianhong XI,Mengchang HE,Kunpeng WANG,Guizhi ZHANG
期刊论文
Screening of textile finishing agents available on the Chinese market: An important source of per- and
Mehvish Mumtaz, Yixiang Bao, Wenchao Li, Lingxiao Kong, Jun Huang, Gang Yu
期刊论文
Discovery of novel ursolic acid derivatives as effective antimicrobial agents through a ROS-mediated
期刊论文
Discovery of cryptolepine derivatives as novel promising agents against phytopathogenic bacteria
期刊论文
Antimicrobial activity of topical agents against Propionibacterium acnes: an in vitro study of clinical
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期刊论文
Triterpenoid inducers of Nrf2 signaling as potential therapeutic agents in sickle cell disease: a review
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期刊论文